RBr07 injection for chronic kidney disease
RBr07 is an injectable RNA therapeutic, a 'splice-switching oligonucleotide' or SSO, which increases esRAGE in the kidney. esRAGE is a naturally occurring, anti-inflammatory spliceoform of RAGE.
RBr07 is under investigation for chronic kidney disease, including diabetic kidney disease.
RBr07 is designed to switch the equilibrium back towards healthy levels of esRAGE in damaged areas of the kidney, inhibit pro-inflammatory RAGE signalling, and protect the kidney against further damage.